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this was even greater when the first-degree relative was diagnosed at a young age and/or in individuals with multiple affected family members 152

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Active Akt phosphorylates multiple targets including Bad (preventing it from inhibiting anti-apoptotic Bcl-2), MDM2 (stabilizing p53), FOXO transcription factors (preventing pro-apoptotic gene expression), mTOR (promoting protein synthesis)

By doing so, it promotes a sense of calmness, relaxation, and mental clarity