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These nonspecific cuts are a limitation to their clinical application

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Although the above experimental and clinical studies have demonstrated the feasibility of metformin in treating gliomas, including suppressing cell proliferation and extending survival, these findings provide new strategies and directions for metformins application in glioma treatment

Nucleic Acids Res 39(16):72237233 Turley SD, Dietschy JM (1978) Re-evaluation of the 3 alpha-hydroxysteroid dehydrogenase assay for total bile acids in bile