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Dysmenorrhea in adolescents and young adults: etiology and management

106 Additionally, peripheral administration of PP has been seen to decrease food intake in obese and lean rodents and ob/ob mice are not as sensitive to the peptides actions

In experimental models, diabetes reduces NGF expression in target tissues including skin and muscle, impairing retrograde transport to neuronal cell bodies and decreasing neuropeptides such as substance P and calcitonin gene-related peptide [146]

SOCS1 (suppressor of cytokine signaling 1) protein is a negative regulator of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway and has tumor suppressor activity