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286 This sensor has more than six cysteine residues in different structural elements and several other putative metal binding sites

The human gene for the heavy subunit has been localized to chromosome 6p12 [10] and the gene for the light subunit to chromosome 1p21 [11]

Similarly, inhibiting glutathione reductase (GR), which converts oxidized glutathione (GSSG) to GSH, with 2-AAPA induced oxidative stress, leading to the suppression of melanoma metastasis in vitro and in vivo [33]