Throughout puberty and the post-pubertal period, girls with polycystic ovarian syndrome, a hallmark of adrenarche, experienced symptoms like PCOS, which were linked to acute stimulation of the gonadotropin-releasing hormone (GnRH)
Resistant cells generate more glutathione, elicit nuclear factor erythroid 2-related factor 2 (NRF2) activation, and overexpress many anti-oxidative genes such as superoxide dismutase, catalase, glutathione peroxidase, and thioredoxin reductase, providing stronger antioxidant capacity to survive in a more oxidative environment due to the sharp rise in oxidative metabolism and reactive oxygen species generation
As loss of ATM correlates with decreased pigmentation in hair follicle melanocytes it is difficult to determine if loss of melanin contributes to a reduction in ATM expression or drives the process of ATM loss more rapidly
Farquharson J, Adams JF
The extent to which this impacted lipogenic products (i.e., fatty acids and triglycerides) and whether this was connected to NRF2 activation was unclear