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Bax oligomerizes in the mitochondrial outer membrane, forming channels that facilitate the release of cytochrome c into the cytoplasm, subsequently activating Caspase-9, which then triggers Caspase-3 activation through a caspase cascade

NO overrelease in vitro) (Sikiric et al., 1997)

Physiology (Bethesda) 245 Roselli-RehfussL.MountjoyK