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7 Over 55% of the weighting in this meta-analysis was contributed by the LOOK AHEAD trial, which assessed whether intensive lifestyle interventions for weight loss would reduce cardiovascular morbidity and mortality in individuals with overweight or obesity and type 2 diabetes (T2DM)

Suppression of mTOR signaling pathway triggered autophagy

This sustained decline culminates in severe, long-lasting consequences for both overall health and the quality of life (6)