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Collectively, it may be hypothesized that obesity induces feedback inhibition of pituitary GH secretion by increasing non-fasting serum FFA levels and the associated insulin resistance that causes compensatory intra-portal hyperinsulinemia and IGFBP-1 suppression, with the net result being low GH and normal IGF-I levels

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In preclinical models, NNMT inhibition has been shown to mimic and boost exercise-mediated improvements in muscle function, even in sedentary subjects

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