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This review examines the major mechanisms between obesity and AD, which focus on the effect on skin and gut microbiota, immune responses mediated by the toll like receptor (TLR) signaling pathway, and changes in cytokine levels (TNF-a, IL-6, IL-4, and IL13)

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This is a major factor in the skin becoming rough, dry, and vulnerable to damage

Figure 3A shows that LPS markedly induced the phosphorylation of NF-kB p65 at Ser536 in RAW 264.7 cells, while the treatment with GHK-Cu (1, 5, and 10 M) inhibited the LPS-stimulated phosphorylation of NF-kB p65 at Ser536