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Ipamorelin demonstrates a selectivity profile where GH release occurs at doses that do not significantly alter cortisol, prolactin, or appetite effects that are prominent with GHRP-6 at comparable GH-releasing doses

As such, BPC-157 is utilised as a molecular probe for investigating peptide-mediated signalling behaviour rather than defined biological or physiological outcomes

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, Dringen R., Sandberg M., and Hamprecht B

Interestingly, recently germline or somatic duplication of GPR101 constitutively activates the cAMP pathway in the absence of a ligand, leading to GH release