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For example, ferroptotic macrophages have the ability to generate HMGB1, a DAMP that triggers the release of pro-inflammatory cytokines, including IL-1 and IL-18, and activates the inflammasome (61)

The mitochondrial DOX-Fe 2+ complex induces triggers lipid peroxidation, resulting in mitochondria-dependent ferroptosis and decreased cardiac function in mice, which is reflected in significantly reduced left ventricular ejection fraction and myocardial fibrosis

Diabetic neuropathy: mechanisms, emerging treatments, and subtypes

For the untargeted experiment, proteins were digested with 0.7 g of trypsin (sequencing grade, Promega, Madison, WI) and 0.7 g of Lys-C (New England Biolabs) for 1 h at 37 C

J., Johnson, G