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J Headache Pain 19(1):55 Wang W, Zhang X, Bai X et al (2023) Changes in gamma-aminobutyric acid and glutamate/glutamine levels in the right thalamus of patients with episodic and chronic migraine: A proton magnetic resonance spectroscopy study

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Melatonin can also chelate Cu 2+ , reduce Fe 2+ , Zn 2+ , Al 3+ , Mn 2+ , and other toxic metal ions (60), reduce metal ion-catalyzed molecular damage, and suppress metal ion interaction with -amyloid peptides to produce free radicals (61), playing significant antioxidant and protective roles in the body

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