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B., Quintanilla R

In addition, in an HHcy-induced 2-kidney, 1-clip (2K1C) hypertensive murine model and Hcy-B CM-treated glomerular endothelial cells (GECs), a significant increase in the ferropotosis rate was triggered through iron accumulation, lipid peroxidation, upregulation of TFR1, and downregulation of SLC7A11 and GPX4 [262]

Sources Lin, T.-K

Those who dont have a B12 deficiency may not notice much of a change because their bodies will flush out the extra B12

By directly reducing ROS production, it protects cells from oxidative stress, a process implicated in both type 1 and type 2 diabetes as well as other pathophysiological conditions