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For long-term storage, keep at 2C 8C (Refrigerated)

When the supply of amino acids is reduced, it affects the renewal of cells, which causes, in particular, the thinning of the dermis

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

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Regardless of treatment adherence, the data gathered from all participants of the study indicated a similar decrease in weight from baseline levels