Given the above, we speculated that in the control of GH, the 2 -adrenergic neurons are located distally to the cholinergic neurons, so that the latter contribute to GH secretion by modulating the functional activity of the former, as occurring in peripheral tissues
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Specifically, it has been reported that H 2 O 2 -dependent inactivation of autophagy-related gene-4 ( ATG4 ) increases LC3-associated autophagosomes and that ATM-mediated oxidation of AMP-activated protein kinase (AMPK) inhibits mammalian target of rapamycin 1 (TORC1), a pivotal negative regulator of autophagy 115,116,117 (Fig
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