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Overall, GWAS have either failed to identify genes responsible for bipolar disorder, due to relatively small individual contributions, inadequate sample size, or disease heterogeneity (21, 30), or they have identified genes involved in housekeeping functions, such as translation, transcription, energy conversion, and metabolism (32)

Antioxidant response against oxygen radicals of endogenous or exogenous sources Superoxide dismutase, catalase and glutathione peroxidase are antioxidant enzymes which do not only play fundamental but indispensable role in the antioxidant protective capacity of biological systems against free radical attack

Reduce Depletion Minimising the factors that deplete glutathione helps preserve existing levels

Targeting GPX4 in human cancer: implications of ferroptosis induction for tackling cancer resilience

Nonetheless, there is extensive evidence that monomethylated forms of Se such as methylselenol are critical metabolites for the chemopreventive effect of Se ( Reference Ip, Thompson and Zhu 30 )