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Theres therefore a strong mechanistic case for providing older adults with extra NAD+

Because cuproptosis preferentially targets cells with high oxidative phosphorylation (OXPHOS) dependency, whereas glycolytic tumors remain relatively resistant, it exposes a distinct metabolic vulnerability in cancer and presents unique therapeutic opportunities 165,166

Discussion Metabolic reprogramming, characterized by altered utilization of energy pathways, has emerged as a hallmark of cancer cells, enabling sustained proliferation and tumor growth 23

Nat Rev Drug Discov 7:759-770

Parra ER, Villalobos P, Behrens C, Jiang M, Pataer A, Swisher SG , William WN Jr, Zhang J, Lee J, Cascone T, Heymach JV, Forget MA, Haymaker C, Bernatchez C, Kalhor N, Weissferdt A, Moran C, Zhang J, Vaporciyan A, Gibbons DL, Sepesi B, Wistuba II