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Mental Health Comorbidities and Co-Occurring Disorders The impact of co-occurring psychiatric conditions on escalation risk includes: Co-occurring anxiety disorders, major depressive disorder, conduct disorder, and PTSD each independently increase the probability of progressing from gateway substance use to harder drug use, with each additional internalizing disorder associated with a 20 to 50% increase in risk of developing clinically significant substance dependence

However, several of them had an issue with how it happened