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118 Autoradiographic and radioligand binding experiments have localized AT 4 binding sites on microvilli and cell bodies of rat proximal convoluted and straight tubules, 17 cultured rat mesangial cells, 111 cultured opossum proximal tubule cells, 119 apical and basolateral membranes of rabbit cortical tubules, 119 cultured rabbit 120 and human collecting duct cells 121 and cultured human proximal tubule epithelial cells
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Clean handling, careful storage, and tidy reconstitution keep the process stable
In some embodiments, an otic composition or formulation disclosed herein comprises less than about 10 ppm of each of alcohols, propylene glycol, and cyclohexane
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