this leads to glycation, which increases ROS production
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47 Taken together, these data suggest the reduced GSH/GSSG antioxidant capacity is insufficient to counter excessive OH production, and that unopposed OH can reach the nucleus to create the oxidative DNA adduct, 8-oxo-dG
In a still further particular aspect, the indication is (iv)
As indicated in the text and figure legends, four to six biological replicates from mutants and controls at two ages (3 months and 8 months, male mice) were used for this experiment