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2017 NNMT knockdown in adipocytes was associated with improved markers of insulin sensitivity and glucose uptake in preclinical in vitro models, linking NNMT to metabolic homeostasis

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It was found through preliminary research that treatment with AOD9604 over the course of 14 days in obese mice led to decreased body weight and body fat and was shown to increase the activity of the beta(3)-adrenergic receptors in the fat cells to the same level as those in lean mice

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