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Together, these data indicate that antibody production and plasma cell differentiation are inversely related to G6PD activity

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W., et al

While these studies focus on cancer cells, they reveal that G6PD is an important negative regulator of cell intrinsic causes of ferroptosis

Accordingly, the World Health Organization classifies G6PD-d based on the level of residual G6PD activity, with severe deficiency (Class I) causing chronic nonspherocytic hemolytic anemia and the least severe deficiency (Class IV) with little-to-no appreciable phenotype 8,11