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Safety Concerns and Contraindications Despite favorable preclinical profiles, theoretically plausible adverse effects exist based on BPC-157s mechanisms

Both familial (fALS, 510% of cases) and sporadic (sALS) forms show similar clinical and pathological features, with overlapping cognitive and behavioral changes, particularly frontotemporal-like symptoms, as well as progressive bulbar and limb motor dysfunction

But those studies only show correlations

Typical working concentrations for cellular studies are 0.1-10 mM

All research subject gave written information consent prior to inclusion in the study, and all human studies were approved by the Cleveland Clinic institutional review board