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Methods in Enzymology
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A link between gastrointestinal disorders and migraine: insights into the gutbrain connection
doi:10.1038/ng1293-344
Nonetheless, future research should explore if the increased NO generation in Long COVID results in nitrosative stress associated with hypernitrosylation (increased NO or nitroso binding), which has a variety of neurotoxic consequences [90]
The above notion could reconcile the paradox of EBV exposure being a strict requirement for subsequent development of MS, and on the other hand the recent failure of an EBV-specific T-cell therapy (Giovannoni et al., 2024): if early EBV infection triggers a molecular cascade driving MS pathogenesis that no longer requires replication of virus, anti-viral therapies begun once MS is clinically evident may be doomed to failure
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