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It was also effective during phase 1 but not during phase 2, as determined by the formalin test

The ensuing oxidative stress activates NF-B signaling, stimulates neuroinflammatory glial responses, and promotes P2X purinoceptor 7 (P2X7R)-mediated inflammasome assembly, thereby establishing a self-perpetuating cycle of neurodegeneration (Lee and Hyun, 2023