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Patients with a history of chronic hepatitis B or hepatitis C virus infection, HIV/AIDS, TB, uncontrolled T2DM, SARS-CoV2 infection within 6 months, and a history of alcohol abuse within 6 months were excluded

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These observations may help explain why RA is a site-specific manifestation of a systemic autoimmune disease, in which early cartilage damage in the context of altered immune activation leads to a specific cellular activation of FLS within the articular joints