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Consider dose reduction in hepatic failure

Conformational changes induced by compound binding are not detected at this resolution

Smith RG, Thorner MO (Eds) Humana Press Inc., Totowa, NJ, 2000, pp 17-43 Muccioli G, et al

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Moreover, some ATF members can directly or indirectly recruit ATP-dependent chromatin-remodeling complexes, altering nucleosome positioning and conformation to reorganize the chromatin landscape (112)