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2c) in transplantation settings, consistent with previous reports that SIRT3 preserves HSC maintenance by limiting oxidative stress and promoting quiescence and survival 30,37

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Furthermore, studies on serum from SZ patients showed elevated levels of polyamine oxidase (the enzyme responsible for degrading PAs) (96, 97), while the activities of three enzymes involved in PA synthesisornithine aminotransferase, antizyme inhibitor 1 (AZIN1), and ornithine cyclodeaminase were found to be reduced in the prefrontal cortex of both treated and untreated patients (98), ultimately potentially leading to disrupted polyamine homeostasis

Preclinical studies show minimal toxicity in research models, though some reports note temporary fatigue, nausea, or mild injection-site irritation

It also has antioxidant properties that protect brain cells from oxidative stress