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As an accumulation of DNA methylation of intrinsic factors, such as Sox 2, NeuroD 1 and NeuroD2 , has been detected in cultured astrocytes and in the aged cortex (Siegmund et al., 2007

Mycotoxins generate reactive oxygen species (ROS) and deplete antioxidant reserves, contributing to cellular damage and mitochondrial dysfunction 32

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Through his ambitious programme known as Blueprint , Johnson aims to slow and potentially reverse aspects of biological ageing using data, nutrition, and targeted supplementation