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The Alcoholic Beverage Labeling Act (ABLA) of the Anti-Drug Abuse Act of 1988, requires alcoholic beverages to warn: (1) According to the Surgeon General, women should not drink alcoholic beverages during pregnancy because of the risk of birth defects

This contradictory effect on metabolism of estrogens strictly depends on PAHs chemical structure and on the diversity of the complex PAHs mixture present in air pollution and in tobacco smoke and their metabolites occur after entering to the body [23, 45,46,47]

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