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Antioxidant defense via Nrf2 pathway activation Oxidative stress, the accumulation of reactive oxygen species that damage cells, mitochondria, and DNA, is a foundational driver of accelerated aging

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It is more stable than the reduced form and is not oxidized in the gastrointestinal tract

These studies showed that the translation of zinc (Zn)-induced or genetically upregulated MTs in the pancreas prevented the development of spontaneous or chemically-induced diabetes [21]

CORRESPONDING AUTHOR: Olivia Avidan MD Department of Internal Medicine Warren Alpert Medical School of Brown University Rhode Island Hospital Providence, RI 02903 Email: [email protected]