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\n\n\n\n The core mechanisms angiogenesis stimulation through VEGF and VEGFR2 upregulation, nitric oxide pathway modulation, growth hormone receptor sensitization, mTOR pathway interaction, and cytokine regulation provide a coherent and plausible biological framework for understanding the diverse effects observed across species and tissue types in animal studies

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68 A systematic, evidence-based review 9 concluded that corticosteroid injections appear to be relatively safe and seem to have a short-term effect (two to six weeks)