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The authors reported that these effects were associated with reduced apoptosis during the in vitro aging window and suggested that Epitalon may delay oocyte aging through modulation of mitochondrial activity and oxidative stress

The applicant provided 5 studies to support these claims, as well as 11 background articles about CDI recurrence and risks of increased exposure to antibiotic therapies in a hospital setting for rCDI and cardiac risk of prescribing existing treatments, such as ZINPLAVA TM , to patients with pre-existing heart failure

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Table 3 shows a significant increase in estrogen levels of 22.754ng/ml (p=0.001) compared to the control group, which increased by 3.598ng/ml (p=0.134)