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Knockout of mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 (mtGPAT1), a major hepatic glycerol-3-phosphate acyltransferase, decreased de novo DAG generation protecting mice from hepatic insulin resistance (195)

The tb-500 peptide side effects documented in available research are generally mild and well tolerated

Phase IIb ran to 24 weeks without reported safety signals

The presence of benzyl alcohol allows the solution to remain sterile for multiple uses over time, typically up to 28 days after first puncture, unlike sterile water which must be discarded after a single use

Journal of Molecular Medicine, 95(3), 323333