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Long Journal of the American Chemical Society 1960 82 (4), 795-798 DOI : 10.1021/ja01489a008 This is the paper giving the pK a of water as 15.7 whose methods are criticized in the above articles

The target protein can then be obtained by changing the elution conditions

They're the conditions under which the peptides function as designed

Contrarily to the other methods listed before, vaccine-based approaches do not only aim to target senescent cells in tissues, but also senescent immune cells, which can be responsible for age-related diseases 60