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Targets stubborn visceral and subcutaneous fat 24/7 fat burning with increased metabolic rate Preserves muscle during caloric deficits Improves overall body composition "I feel better, more energetic and I'm losing fat and gaining muscle like I wanted." WRC Patient, 3 months on therapy 2

Participants were randomized in a 2:1:1:1:1:2:2 ratio to once-weekly subcutaneous retatrutide at 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, over a 48-week treatment period

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[Accessed on 4th November 2022] 6

And tirzepatide GI effects can cause fluid loss