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LPAR1 also facilitates androgen-independent growth by enhancing AR nuclear localization (40)

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Recent investigations have revealed that ferroptosis involves alterations in iron metabolism regulatory proteins (e.g., GPX4, TfR1), accumulation of lipid peroxidation products, and dysregulation of antioxidant systems, particularly the nuclear factor E2-related factor 2 (Nrf2)/glutathione peroxidase 4 (GPX4) pathway (8, 9)