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Tindemans I, Joosse ME, and Samsom JN

KPV: The Anti-Inflammatory Tripeptide From -MSH KPV is the quietest and least-studied of the four, and also the one whose evidence base is most clearly labeled preclinical only. It is a tripeptide lysine-proline-valine corresponding to the C-terminal three residues (positions 1113) of -melanocyte-stimulating hormone

Prescribers should present compounded formulations as clinically reasonable options within a shared decision-making framework, not as guaranteed solutions

Heightened systemic inflammatory states appear to worsen COVID-19 outcomes by initiating a counter-regulatory response, which includes the upregulation of levels of the ACE2 receptor and its associated peptidases 11

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