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Your body needs vitamin B12 (cyanocobalamin) to break down fat and carbohydrates for energy, and to make proteins and cells

Since Fe(II) catalyzes the Fenton reaction to produce the free radical OH * from hydrogen peroxide, its upregulation presents a paradox: Nrf2 also boosts the expression of the genes encoding several components of the ferritin complex that detoxifies Fe(II) by converting it to Fe(III) and then stores it 22

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FIGURE 1 Characterization of differentiated hepatocyte-like cells Human iPSCs were first differentiated into definitive endoderm (DE) cells, followed by hepatoblast specification and subsequent maturation into HLCs

Wei et al, 2024