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While a high dietary intake of the vitamin rarely causes high vitamin B12, excess usually results from supplementation or injections

[1] [4] Published phase 2 trial data (Jastreboff et al., NEJM , 2023) reported dose ranges from 1 mg up to 12 mg weekly, with higher doses associated with greater weight loss but also increased rates of gastrointestinal side effects

Potent upregulation of glutathione and Nad(P)H:Quinone oxidoreductase 1 by alpha-lipoic acid in human neuroblastoma Sh-Sy5y cells: protection against Neurotoxicant-elicited cytotoxicity

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A neurologist may be able to detect the Cogwheel phenomenon