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From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment

This addiction primarily stems from the presence of nicotine, a potent psychoactive substance found in tobacco, according to an article by the Center of Addiction and Mental Health titled Nicotine Dependence. The addictive nature of tobacco leads individuals to develop a tolerance, necessitating higher amounts to achieve the same effects, ultimately reinforcing the cycle of dependence

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In the MR Steiger directionality test, the variance explained by included SNPs is larger in schizophrenia, bipolar disorder and anxiety compared with smoking initiation, suggesting that these observed associations might not be directionally causal