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By suppressing TGF-1 expression and preventing Smad2/3 phosphorylation, luteolin downregulates core ECM components, such as collagen I, fibronectin, and alpha-smooth muscle actin (-SMA), thereby limiting myofibroblast activation and pathological ECM accumulation

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Methylation is complex to say the least, if you have any of the symptoms on this page it is best to contact one of our professionals who understand methylation and how to correct imbalances.

Further research on rotator cuff injuries demonstrated similar benefits