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Several studies showed evident association between type II diabetes and cancer, in particular in liver and pancreas, organs persistently exposed to high levels of endogenous insulin 117,118,119

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SLE patients also have lower hematocrit levels compared to healthy individuals and exhibit a higher percentage of PS-exposing erythrocytes, elevated cytosolic Ca 2+ levels, abundance of ROS, and significant erythrocyte shrinkage [327, 328]

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