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This may contribute to its observed effect durability

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Recent studies and meta-analysis report a higher occurrence of RA in patients with moderate to severe periodontitis compared to controls, and a higher prevalence of periodontitis and periodontal destruction in RA subjects compared to non-RA subjects 6,7,8,9,10,11,12

Their considerable result as a substitution for delivering the therapeutic constituent to the desired region has been employed to extend the therapeutic profile and minimize the risk of side effects associated with anticancer medications [418]