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The primary metabolite, phosphoramide mustard, is a nitrogen mustard molecule considered the most therapeutically effective metabolite owing to its significant ability to induce DNA damage by intercalating between the two strands (Vredenburg et al

Constipation or diarrhea 1015%

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The reduced precursors NRH and NMNH show promise in overcoming this, although preclinical evidence for health benefits is still limited, and whether their efficacy on functional readouts would be superior to the classic counterparts NR and NMN is also unclear

K.BloiseE.et al (2012)