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Trp53 fl/fl (AKP) mice 72 h post-tamoxifen intraperitoneal (i.p.) injection and cultured in 3D as previously reported (Extended Data Fig

Activation promotes neuronal survival, axon growth, synaptic plasticity

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The peptide's activation of ERK1/2 and downstream transcription factors including Egr-1 drives expression of collagen synthesis genes while its enhancement of cellular migration ensures efficient fibroblast recruitment to sites requiring matrix deposition, creating optimal conditions for rapid yet organized tissue reconstruction

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