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Half of studied acute craving episodes lead to lapse within 11 minutes 35 Nicorette Quickmist Mouthspray is clinically proven to start relieving cravings in 30s 11 A maximum concentration of 5.3 ng/mL is reached within 13 minutes after administration of a 2 mg dose 36 Nicorette : faster-acting formats: relieve sudden cravings whenever they strike Faster-acting Nicorette formats such as: QuickMist Mouthspray, Gum, Lozenge, Inhalator or Nasal Spray are absorbed by the oral or nasal mucosa 7 Can be used to prevent and/or relieve sudden cravings when they strike 5 Cytisine: Indicated for reduction of nicotine cravings in smokers who are willing to stop smoking 18 Varenicline: Indicated to help relieve the craving and withdrawal symptoms associated with stopping smoking 19 To keep in mind: With NRT your patients can get craving relief when they strike 7 Support your patient by asking whether they smoke, and recommend stop smoking medication like Nicorette Combination Therapy Nicorette Combination Therapy: Combining two formats for Nicorette Combination Therapy can help to manage nicotine withdrawal symptoms with a long acting patch and a flexible format for cue induced or breakthrough cravings Patch relieves smoking cravings discreetly and continuously over 16 hours 37 , and doesn't add to sleep disturbance Mouthspray starts to relieve withdrawal symptoms in just 30 seconds 11 Nicorette Combination Therapy options 11,37-42 Slama KJ et al

Nicotine Strengths: 20, 35mg and 55mg