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Together, these results suggest that adipose tissue lipolysis plays a major role in the development of nicotine plus HFD-induced hepatic steatosis

Pharmacological and toxicological studies support the biological plausibility that nicotine contributes to acute cardiovascular events and accelerated atherogenesis

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It is prudent to carefully examine biopsies for malignant changes, as the level of epithelial dysplasia may guide the choice of surgical intervention or monitoring