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To gather relevant publications, we searched several databases such as PubMed, EBSCO, Cochrane, and Science Direct, using specific MESH terms and keywords such as cigarette smoking, air pollution, particulate matter, gaseous air pollutants, cardiovascular diseases, and hypertension. To ensure the quality of the studies, we applied PECOS criteria that focused on the population (i.e., adults chronically exposed to outdoor air pollutants), comparator (unexposed persons), result (all-cause mortality and cardiovascular diseases), and study design (experimental and epidemiological studies, intervention studies, meta-analyses, and systematic reviews published in peer-reviewed journals in English)

5.1 Fusion and fission processes in mitochondria Mitochondria form a highly dynamic network within the cell through continuous processes of fusion and fission

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Diacetyl is a food additive used in e-cigarettes for flavoring that is known to cause damage to the lung passageways