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Why do some people report weight gain instead

Nature Medicine, 30(6), 1639-1647

By weeks 5 through 8, more substantial structural changes emerge tissue resilience improves, stiffness decreases, and strength recovery accelerates

Prednisone can cause side effects such as: Increased appetite and weight gain Difficulty sleeping Mood changes Higher risk of infections Fluid retention Skin changes Elevated sugar Gastrointestinal problems Always report any unusual symptoms to your doctor right away

As a doctor, theres a lot of burden on your shoulders when you are prescribing something with insufficient evidence, but the patients insist on giving it a try. With no formal approvals surrounding their use from regulatory bodies like the Drugs Controller General of India (DCGI), they are considered off-label treatments